Compile Data Set for Download or QSAR

Found 253 hits of ec50 data for polymerid = 10879,6944,7406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268750 (CHEMBL4064391) Show SMILES O=C(COc1ccc2CCCc2c1)N(Cc1cccs1)c1ccn[nH]1 Show InChI InChI=1S/C19H19N3O2S/c23-19(13-24-16-7-6-14-3-1-4-15(14)11-16)22(18-8-9-20-21-18)12-17-5-2-10-25-17/h2,5-11H,1,3-4,12-13H2,(H,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.00100	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268748 (CHEMBL4069241) Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(Cc1cccs1)c1ccn[nH]1 Show InChI InChI=1S/C18H15N3O3S/c22-18(6-4-13-3-5-15-16(10-13)24-12-23-15)21(17-7-8-19-20-17)11-14-2-1-9-25-14/h1-10H,11-12H2,(H,19,20)/b6-4+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.00200	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268747 (CHEMBL4070838) Show SMILES Cc1ccc(\C=C\C(=O)N(Cc2cccs2)c2ccn[nH]2)cc1 Show InChI InChI=1S/C18H17N3OS/c1-14-4-6-15(7-5-14)8-9-18(22)21(17-10-11-19-20-17)13-16-3-2-12-23-16/h2-12H,13H2,1H3,(H,19,20)/b9-8+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.00400	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268769 (CHEMBL4087522) Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccn[nH]2)cc1 Show InChI InChI=1S/C17H17N3O2S/c1-13-4-6-14(7-5-13)22-12-17(21)20(16-8-9-18-19-16)11-15-3-2-10-23-15/h2-10H,11-12H2,1H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268764 (CHEMBL4099556) Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ncco2)cc1 Show InChI InChI=1S/C17H16N2O3S/c1-13-4-6-14(7-5-13)22-12-16(20)19(17-18-8-9-21-17)11-15-3-2-10-23-15/h2-10H,11-12H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268773 (CHEMBL4075397) Show SMILES Cc1n[nH]c(C)c1N(Cc1cccs1)C(=O)COc1ccc(C)cc1 Show InChI InChI=1S/C19H21N3O2S/c1-13-6-8-16(9-7-13)24-12-18(23)22(11-17-5-4-10-25-17)19-14(2)20-21-15(19)3/h4-10H,11-12H2,1-3H3,(H,20,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268837 (CHEMBL4072494) Show SMILES Cc1n[nH]cc1N(Cc1cccs1)C(=O)COc1ccc(C)cc1 Show InChI InChI=1S/C18H19N3O2S/c1-13-5-7-15(8-6-13)23-12-18(22)21(11-16-4-3-9-24-16)17-10-19-20-14(17)2/h3-10H,11-12H2,1-2H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268749 (CHEMBL4097005) Show SMILES O=C(COc1ccc2OCOc2c1)N(Cc1cccs1)c1ccn[nH]1 Show InChI InChI=1S/C17H15N3O4S/c21-17(10-22-12-3-4-14-15(8-12)24-11-23-14)20(16-5-6-18-19-16)9-13-2-1-7-25-13/h1-8H,9-11H2,(H,18,19)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.600	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268746 (CHEMBL4097943) Show SMILES CCN(Cc1cccs1)C(=O)\C=C\c1ccc2OCOc2c1 Show InChI InChI=1S/C17H17NO3S/c1-2-18(11-14-4-3-9-22-14)17(19)8-6-13-5-7-15-16(10-13)21-12-20-15/h3-10H,2,11-12H2,1H3/b8-6+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.700	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268828 (CHEMBL4079591) Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc2CCCc2c1 Show InChI InChI=1S/C18H21NO2S/c1-2-19(12-17-7-4-10-22-17)18(20)13-21-16-9-8-14-5-3-6-15(14)11-16/h4,7-11H,2-3,5-6,12-13H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268729 (CHEMBL4060261) Show SMILES COc1ccc2oc(cc2c1)C(=O)N(Cc1cccs1)c1ccn[nH]1 Show InChI InChI=1S/C18H15N3O3S/c1-23-13-4-5-15-12(9-13)10-16(24-15)18(22)21(17-6-7-19-20-17)11-14-3-2-8-25-14/h2-10H,11H2,1H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268770 (CHEMBL4105385) Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2cn[nH]c2)cc1 Show InChI InChI=1S/C17H17N3O2S/c1-13-4-6-15(7-5-13)22-12-17(21)20(14-9-18-19-10-14)11-16-3-2-8-23-16/h2-10H,11-12H2,1H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268835 (CHEMBL4063252) Show SMILES CCN(Cc1cccs1)C(=O)\C=C\c1ccc(C)cc1 Show InChI InChI=1S/C17H19NOS/c1-3-18(13-16-5-4-12-20-16)17(19)11-10-15-8-6-14(2)7-9-15/h4-12H,3,13H2,1-2H3/b11-10+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268763 (CHEMBL4064052) Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccon2)cc1 Show InChI InChI=1S/C17H16N2O3S/c1-13-4-6-14(7-5-13)21-12-17(20)19(16-8-9-22-18-16)11-15-3-2-10-23-15/h2-10H,11-12H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268724 (CHEMBL4091381) Show SMILES COc1ccc(OCC(=O)N(Cc2cccs2)c2ccn[nH]2)cc1 Show InChI InChI=1S/C17H17N3O3S/c1-22-13-4-6-14(7-5-13)23-12-17(21)20(16-8-9-18-19-16)11-15-3-2-10-24-15/h2-10H,11-12H2,1H3,(H,18,19)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268841 (CHEMBL4071703) Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)C2CC2)cc1 Show InChI InChI=1S/C17H19NO2S/c1-13-4-8-15(9-5-13)20-12-17(19)18(14-6-7-14)11-16-3-2-10-21-16/h2-5,8-10,14H,6-7,11-12H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268832 (CHEMBL4096839) Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(C)cc1 Show InChI InChI=1S/C16H19NO2S/c1-3-17(11-15-5-4-10-20-15)16(18)12-19-14-8-6-13(2)7-9-14/h4-10H,3,11-12H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268745 (CHEMBL4087060) Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(C)cc1O Show InChI InChI=1S/C16H19NO3S/c1-3-17(10-13-5-4-8-21-13)16(19)11-20-15-7-6-12(2)9-14(15)18/h4-9,18H,3,10-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268810 (CHEMBL4095201) Show SMILES CON(Cc1cccs1)C(=O)COc1ccc(C)cc1 Show InChI InChI=1S/C15H17NO3S/c1-12-5-7-13(8-6-12)19-11-15(17)16(18-2)10-14-4-3-9-20-14/h3-9H,10-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50269660 (CHEMBL4067554) Show SMILES COc1cc(ccc1O)C(O[C@H]1C[C@@H](C)CC[C@@H]1C(C)C)C(C)Oc1c(OC)cc(CC=C)cc1OC |r| Show InChI InChI=1S/C31H44O6/c1-9-10-22-16-28(34-7)31(29(17-22)35-8)36-21(5)30(23-12-14-25(32)27(18-23)33-6)37-26-15-20(4)11-13-24(26)19(2)3/h9,12,14,16-21,24,26,30,32H,1,10-11,13,15H2,2-8H3/t20-,21?,24+,26-,30?/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268756 (CHEMBL4092493) Show SMILES Cc1ccc(OCC(=O)N(CC=C)Cc2cccs2)cc1 Show InChI InChI=1S/C17H19NO2S/c1-3-10-18(12-16-5-4-11-21-16)17(19)13-20-15-8-6-14(2)7-9-15/h3-9,11H,1,10,12-13H2,2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268762 (CHEMBL4091813) Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccccc2)cc1 Show InChI InChI=1S/C20H19NO2S/c1-16-9-11-18(12-10-16)23-15-20(22)21(14-19-8-5-13-24-19)17-6-3-2-4-7-17/h2-13H,14-15H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	23	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268735 (CHEMBL4059464) Show SMILES CCN(Cc1cccs1)C(=O)COc1cc(C)ccc1O Show InChI InChI=1S/C16H19NO3S/c1-3-17(10-13-5-4-8-21-13)16(19)11-20-15-9-12(2)6-7-14(15)18/h4-9,18H,3,10-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	24	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50269663 (CHEMBL4076583) Show SMILES COc1cc(ccc1O)C(O[C@@H]1C[C@H](C)CC[C@H]1C(C)C)C(C)Oc1c(OC)cc(CC=C)cc1OC |r| Show InChI InChI=1S/C31H44O6/c1-9-10-22-16-28(34-7)31(29(17-22)35-8)36-21(5)30(23-12-14-25(32)27(18-23)33-6)37-26-15-20(4)11-13-24(26)19(2)3/h9,12,14,16-21,24,26,30,32H,1,10-11,13,15H2,2-8H3/t20-,21?,24+,26-,30?/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268827 (CHEMBL4103845) Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(Cl)cc1 Show InChI InChI=1S/C15H16ClNO2S/c1-2-17(10-14-4-3-9-20-14)15(18)11-19-13-7-5-12(16)6-8-13/h3-9H,2,10-11H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268831 (CHEMBL4078818) Show SMILES CCCN(Cc1cccs1)C(=O)COc1ccc(C)cc1 Show InChI InChI=1S/C17H21NO2S/c1-3-10-18(12-16-5-4-11-21-16)17(19)13-20-15-8-6-14(2)7-9-15/h4-9,11H,3,10,12-13H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268730 (CHEMBL4091183) Show SMILES Cc1ccc2oc(cc2c1)C(=O)N(Cc1cccs1)c1ccn[nH]1 Show InChI InChI=1S/C18H15N3O2S/c1-12-4-5-15-13(9-12)10-16(23-15)18(22)21(17-6-7-19-20-17)11-14-3-2-8-24-14/h2-10H,11H2,1H3,(H,19,20)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50442649 (CHEMBL2441929) Show SMILES COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |r| Show InChI InChI=1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16+,17-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of human TRPM8 (unknown origin) expressed in HEK293 cells assessed as inhibition of WS12-induced Ca2+ elevation by FLIPR assay				Bioorg Med Chem Lett 23: 6118-22 (2013) Article DOI: 10.1016/j.bmcl.2013.09.016 BindingDB Entry DOI: 10.7270/Q2125V4N
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268813 (CHEMBL4094300) Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ccncc2)cc1 Show InChI InChI=1S/C19H18N2O2S/c1-15-4-6-17(7-5-15)23-14-19(22)21(13-18-3-2-12-24-18)16-8-10-20-11-9-16/h2-12H,13-14H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	52	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50269664 (CHEMBL4076657) Show SMILES COc1cc(ccc1O)C(OC1CCCCC1)C(C)Oc1c(OC)cc(CC=C)cc1OC Show InChI InChI=1S/C27H36O6/c1-6-10-19-15-24(30-4)27(25(16-19)31-5)32-18(2)26(33-21-11-8-7-9-12-21)20-13-14-22(28)23(17-20)29-3/h6,13-18,21,26,28H,1,7-12H2,2-5H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50241426 (3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydrop...) Show SMILES Oc1ccccc1N1CC=C(NC1=O)c1cccc(c1)[N+]([O-])=O |c:10| Show InChI InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Ferrara University Curated by ChEMBL					Assay Description Activation of TRPM8 channel				J Med Chem 53: 5085-107 (2010) Article DOI: 10.1021/jm100062h BindingDB Entry DOI: 10.7270/Q2416Z02
					More data for this Ligand-Target Pair				3D Structure (crystal)
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268830 (CHEMBL4060474) Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc2COCc2c1 Show InChI InChI=1S/C17H19NO3S/c1-2-18(9-16-4-3-7-22-16)17(19)12-21-15-6-5-13-10-20-11-14(13)8-15/h3-8H,2,9-12H2,1H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50269681 (CHEMBL4077565) Show SMILES CCCCCCCCCCOC(C(C)Oc1c(OC)cc(CC=C)cc1OC)c1ccc(O)c(OC)c1 Show InChI InChI=1S/C31H46O6/c1-7-9-10-11-12-13-14-15-19-36-30(25-17-18-26(32)27(22-25)33-4)23(3)37-31-28(34-5)20-24(16-8-2)21-29(31)35-6/h8,17-18,20-23,30,32H,2,7,9-16,19H2,1,3-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	66	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268823 (CHEMBL4079334) Show SMILES CCN(Cc1cccs1)C(=O)COc1ccc(CC)cc1 Show InChI InChI=1S/C17H21NO2S/c1-3-14-7-9-15(10-8-14)20-13-17(19)18(4-2)12-16-6-5-11-21-16/h5-11H,3-4,12-13H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	67	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268840 (CHEMBL4089135) Show SMILES CC(C)N(Cc1cccs1)C(=O)COc1ccc(C)cc1 Show InChI InChI=1S/C17H21NO2S/c1-13(2)18(11-16-5-4-10-21-16)17(19)12-20-15-8-6-14(3)7-9-15/h4-10,13H,11-12H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	70	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268728 (CHEMBL4087469) Show SMILES CCN(Cc1cccs1)C(=O)c1cc2cc(OC)ccc2o1 Show InChI InChI=1S/C17H17NO3S/c1-3-18(11-14-5-4-8-22-14)17(19)16-10-12-9-13(20-2)6-7-15(12)21-16/h4-10H,3,11H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50269669 (CHEMBL4065256) Show SMILES COc1cc(ccc1O)C(OC(C)C)C(C)Oc1c(OC)cc(CC=C)cc1OC Show InChI InChI=1S/C24H32O6/c1-8-9-17-12-21(27-6)24(22(13-17)28-7)30-16(4)23(29-15(2)3)18-10-11-19(25)20(14-18)26-5/h8,10-16,23,25H,1,9H2,2-7H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	82	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50269682 (CHEMBL4076994) Show SMILES CCCCCCCCOC(C(C)Oc1c(OC)cc(CC=C)cc1OC)c1ccc(O)c(OC)c1 Show InChI InChI=1S/C29H42O6/c1-7-9-10-11-12-13-17-34-28(23-15-16-24(30)25(20-23)31-4)21(3)35-29-26(32-5)18-22(14-8-2)19-27(29)33-6/h8,15-16,18-21,28,30H,2,7,9-14,17H2,1,3-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	86	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50269676 (CHEMBL4074380) Show SMILES CCO[C@H]([C@H](C)Oc1c(OC)cc(CC=C)cc1OC)c1ccc(O)c(OC)c1 |r| Show InChI InChI=1S/C23H30O6/c1-7-9-16-12-20(26-5)23(21(13-16)27-6)29-15(3)22(28-8-2)17-10-11-18(24)19(14-17)25-4/h7,10-15,22,24H,1,8-9H2,2-6H3/t15-,22+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	87	n/a	n/a	n/a	n/a
Kansei Science Research and Biological Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan. Curated by ChEMBL					Assay Description Agonist activity at full length recombinant human TRPM8 expressed in HEK293 cells assessed as increase in intracellular Ca2+ level pre-incubated for ...				ACS Med Chem Lett 8: 715-719 (2017) Article DOI: 10.1021/acsmedchemlett.7b00104 BindingDB Entry DOI: 10.7270/Q2CZ39N2
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268808 (CHEMBL4105242) Show SMILES CCN(Cc1ccsc1)C(=O)COc1ccc(C)cc1 Show InChI InChI=1S/C16H19NO2S/c1-3-17(10-14-8-9-20-12-14)16(18)11-19-15-6-4-13(2)5-7-15/h4-9,12H,3,10-11H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	88	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268717 (CHEMBL4091126) Show SMILES CCN(Cc1cccs1)C(=O)CCc1ccc(C)cc1 Show InChI InChI=1S/C17H21NOS/c1-3-18(13-16-5-4-12-20-16)17(19)11-10-15-8-6-14(2)7-9-15/h4-9,12H,3,10-11,13H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	93	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50268822 (CHEMBL4077232) Show SMILES CCN(Cc1cccs1)C(=O)COc1cccc(C)c1 Show InChI InChI=1S/C16H19NO2S/c1-3-17(11-15-8-5-9-20-15)16(18)12-19-14-7-4-6-13(2)10-14/h4-10H,3,11-12H2,1-2H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	97	n/a	n/a	n/a	n/a
Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States. Curated by ChEMBL					Assay Description Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...				Bioorg Med Chem Lett 27: 3931-3938 (2017) Article DOI: 10.1016/j.bmcl.2017.04.003 BindingDB Entry DOI: 10.7270/Q25H7JRG
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM435142 (US10584134, Example 1-1) Show SMILES O=C1CCCC2=C1C1(CC3N2CCc2ccccc32)SCCS1 |c:5| Show InChI InChI=1S/C19H21NOS2/c21-17-7-3-6-15-18(17)19(22-10-11-23-19)12-16-14-5-2-1-4-13(14)8-9-20(15)16/h1-2,4-5,16H,3,6-12H2	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
SYMRISE AG; BASF SE US Patent					Assay Description A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...				US Patent US10584134 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2K56
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM435154 (US10584134, Example 2-1 | US10584134, Example 2-15...) Show SMILES COc1cnc(nc1NC(C)C)-c1ccccn1 Show InChI InChI=1S/C13H16N4O/c1-9(2)16-13-11(18-3)8-15-12(17-13)10-6-4-5-7-14-10/h4-9H,1-3H3,(H,15,16,17)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
SYMRISE AG; BASF SE US Patent					Assay Description A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...				US Patent US10584134 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2K56
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM435159 (US10584134, Example 2-5) Show SMILES CC[C@@H](C)Nc1nc(ncc1OC)-c1ccccn1 |r| Show InChI InChI=1S/C14H18N4O/c1-4-10(2)17-14-12(19-3)9-16-13(18-14)11-7-5-6-8-15-11/h5-10H,4H2,1-3H3,(H,16,17,18)/t10-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
SYMRISE AG; BASF SE US Patent					Assay Description A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...				US Patent US10584134 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2K56
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM435160 (US10584134, Example 2-7 | US10584134, Example 2-8) Show SMILES COc1cnc(nc1NC(C)C(C)C)-c1ccccn1 Show InChI InChI=1S/C15H20N4O/c1-10(2)11(3)18-15-13(20-4)9-17-14(19-15)12-7-5-6-8-16-12/h5-11H,1-4H3,(H,17,18,19)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
SYMRISE AG; BASF SE US Patent					Assay Description A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...				US Patent US10584134 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2K56
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM435176 (US10584134, Example 3-1) Show SMILES O=C(\C=C\c1ccc2OCOc2c1)N(C1CCCCC1)c1ccccn1 Show InChI InChI=1S/C21H22N2O3/c24-21(12-10-16-9-11-18-19(14-16)26-15-25-18)23(17-6-2-1-3-7-17)20-8-4-5-13-22-20/h4-5,8-14,17H,1-3,6-7,15H2/b12-10+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
SYMRISE AG; BASF SE US Patent					Assay Description A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...				US Patent US10584134 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2K56
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM435195 (US10584134, Example 3-18) Show SMILES COc1ccc(\C=C\C(=O)N(C2CCCCC2)C2CCCCC2)cc1 Show InChI InChI=1S/C22H31NO2/c1-25-21-15-12-18(13-16-21)14-17-22(24)23(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h12-17,19-20H,2-11H2,1H3/b17-14+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
SYMRISE AG; BASF SE US Patent					Assay Description A test comparable with that previously described in the literature by Behrendt H. J. et al., Br. J. Pharmacol. 141, 2004, 737-745, is carried out. Th...				US Patent US10584134 (2020) BindingDB Entry DOI: 10.7270/Q2FJ2K56
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM435195 (US10584134, Example 3-18) Show SMILES COc1ccc(\C=C\C(=O)N(C2CCCCC2)C2CCCCC2)cc1 Show InChI InChI=1S/C22H31NO2/c1-25-21-15-12-18(13-16-21)14-17-22(24)23(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h12-17,19-20H,2-11H2,1H3/b17-14+	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem		n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8 (Homo sapiens (Human))	BDBM50613650 (CHEMBL5272743) Show SMILES COc1cnc(nc1CC(C)C)-c1ccccn1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	UniChem		n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair

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